用途 | Hexamethonium Bromide |
别名 | Hexamethonium Bromide |
CAS编号 | 55-97-0 |
产地/厂商 | xxjl |
Hexamethonium Bromide
CAS 号:55-97-0
英文名字:Hexamethonium Bromide
质量标准:>98%,AChR拮抗剂
分子式:C12H30N2.2Br
Hexamethonium Bromide
分子式:C12H30N2.2Br 分子量:362.19
产品描述 | Hexamethonium Bromide是一种神经中枢中选择性的神经元烟碱型AChR拮抗剂。 | |||||
靶点 | ||||||
IC50 | ||||||
体外研究 | Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM) causes an increase in the amplitude of nerve-evoked endplate currents (e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM. Hexamethonium Bromide (200 μM) decreases the time constant of decay of both endplate currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs) (by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c. quantal content by 30-40%. | |||||
体内研究 | ||||||
溶解性 | DMSO <1 mg/mL,水 73 mg/mL,乙醇 <1 mg/mL | |||||
稳定性 | 2年 -20°C粉状,6月-80°C溶于DMSO |
武汉欣欣佳丽生物科技有限公司 版权所有(C)2024 XML 技术支持 技术支持: 盖德化工网 食品商务网